Whereas this innate plasticity allows for adaptation to a changing environment, it also implies the potential of epigenetic derailment leading to so-called epimutations.
Due to the innate plasticity of DNA methylation of cytosine bases, environmental cues can induce epigenetic shifts in the timing and intensity of gene expression that may contribute to a physiological acclimation response [ 20].
The existence of a dimeric CMG state, coupled with prior views of Mcm2-7 and the DNA-bound conformation of the Mcm2-7 ATPase domains seen here, highlights the innate plasticity of the MCM ring and the means by which different factors help remodel the helicase to support appropriate loading and activation during the initiation of DNA replication.
In this study, the innate genomic plasticity of M. agalactiae was exploited to design and assess a combination of molecular epidemiological tools to trace the pathogen in different geographic locations and to understand its emergence or re-emergence after eradication campaigns.
Or to investigate under what conditions natural selection favors fixed, non-plastic traits (which do not vary across individuals), cue-driven-switch plasticity (innate instructions for adaptive behavioral development based on experience), or developmental selection (the incremental acquisition of adaptive behavior based on experience).
These findings represent a new direction in research concerning the brain's innate capacity for therapeutic plasticity.
While such studies have examined coral heterotrophy [5], decalcification [6], symbiont exchange [7], and inducible secondary metabolites [8] as mechanisms by which corals can overcome changing ocean conditions, no studies to date have directly studied host immunity and plasticity of innate immunity in field conditions.
The heterogeneity of the metastatic cells within the lung and the liver implied plasticity, whether innate or induced, during the metastatic process.
Further, our study suggests a therapy‐induced plasticity of innate immune cells, resulting in less, but preferentially M2‐polarized macrophages accompanied by an increase in intratumoral T cells.
Because of this innate ability, and the brain's plasticity to recover from injury and slow the effects of aging, we can recapture lost movement skills and improve our posture and health well into our later years.
Overall, our results suggest that the innate immune system has had enough plasticity to play an important role in the adaptation of modern humans to new environments.
