Ribot, J.C. et al. Cutting edge: adaptive versus innate receptor signals selectively control the pool sizes of murine IFN-γ or IL-17-producing γδ T cells upon infection.
That could be why the data obtained from animal and clinical studies are sometimes contradictory proving not for the first time that innate immunity is a "double-edge sword," sometimes beneficial and, at other times disastrous for the host.
Following triggering by their relevant exogenous or endogenous ligands, TLRs provoke secretion of a variety of pro-inflammatory cytokines, which if takes place in a tumor environment might optimize or derange tumor activity, a feature designated as 'double edged sword' of innate immunity.
However, this innate defense system is a double edged sword.
These studies, concerning various clinical conditions, often lead to contradictory conclusions, proving not for the first time that the innate immune response is a "double-edge sword," sometimes beneficial and at other times disastrous for the host.
Carnaud, C. et al. Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells.
Maybe that's akin to some innate fear of heights, maybe there's an evolutionary edge to feeling things like awe, epiphany, transcendence.
And given the streamlined decision-making (compared to government), immense financial resources, innate sense of business urgency and access to cutting edge technology of the major corporations, that is -- in my opinion -- a very positive thing.
Similarly, empirical studies of innateness (via the "visual cliff," in which an infant placed at the edge of a glassed-over "cliff " shows behaviour suggestive of innate depth perception) continue to be seen as epistemologically significant.
Pikovskaya, O. et al. Cutting edge: eomesodermin is sufficient to direct type 1 innate lymphocyte development into the conventional NK lineage.
But unlike the doomed noir figures who allow themselves to fall off the edge, Crosby's characters are saved by an innate musicality that eventually allows them to reconnect with the community they left behind.
