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An indwelling inflated balloon results in lengthy procedure times, additional hospital resources, and logistics (e.g., intensive care unit bed, additional patient transport, additional interventional radiology suite time, and staff) and the innate complications associated with balloons (e.g., balloon rupture).
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Geroldi et al. (25) studied centenarians and found sRAGE levels that were inordinately high, suggesting that sRAGE is a marker of health and/or an innate protective mechanism for complications of diabetes.
Monocytes play an important role in the innate immune response and vascular complications and an abnormal cytokine release may contribute to premature atherosclerosis and reduced immune function in T1D patients [ 4, 5].
A better understanding of the innate immune response may help manage complications while allowing for proper immune progression.
Toll-like receptors (TLRs) are integral parts of the innate immune system and have been implicated in complications of pregnancy.
Development of immunosuppression and degraded innate and adaptive immune responses are well-established complications of sepsis.
Long-term exposure to hyperoxia impairs the innate immune response and increases susceptibility to infectious complications and tissue injury.
In utero alcohol deranges both innate and adaptive immunity, increasing the risk for infectious complications in the neonatal lung (for review, see Giliberti et al., 2013).
Genotyping for innate immune receptors may identify individuals with increased risk for septic complications who should be subject to intensified prophylactic measures.
Although T cell response counters the lack of immune tolerance during PE pregnancy complications, the maternal systemic inflammation is activated by the innate immune system, which leads to neutrophil, monocyte, and NK cell activation.
Recently, several studies have suggested that the innate immunity changes may be associated with type 2 diabetes and diabetic complications [ 9– 11].
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