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These findings led to the hypothesis that NKT and Vγ1.1+Vδ6.3+ T cells represent innate branches of the αβ and γδ T cell lineages, respectively [25].
Both the adaptive and innate branches of immunity are involved [ 12].
Major histocompatibility complex (MHC) class I molecules represent a basic molecular framework that mediates the activation and function of cytotoxic effector cells of the adaptive and innate branches of the immune system, such as CD8+ T cells and natural killer (NK) cells.
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The "activated" phenotype of these γδ T cells parallels that of NKT cells, a finding that has led to the hypothesis that Vγ1.1+Vδ6.3+ T cells represent an innate branch within the γδ T cell lineage [25].
With regard to the innate branch of the response, TSLP acts on mast cells and dendritic cells as well as, according to recent results, natural killer cells.
In addition to the cellular component, complement proteins and barriers such as the skin are constituents of the innate branch of immunity.
These cells, belonging to the innate branch of the immune system, overproduce inflammatory cytokines such as IFNα, LTα and IL1β which in turn activate CD11c expressing myeloid dendritic cells.
Thus lymphocyte activation must be tightly regulated and it was not until major advances in our understanding of the more primitive innate branch of immunity that immunologists recognized the fundamental principle of innate adaptive crosstalk in immune regulation (Iwasaki & Medzhitov, 2004; Medzhitov & Janeway, 1999).
Natural Killer (NK) cells are lymphocytes that belong to the innate immune branch, comprise 5 15% of the peripheral blood lymphocytes and are able to eliminate without prior antigenic stimulation virus-infected and malignantly transformed cells, but to spare normal healthy cells [1] [2].
Particularly, cells of the innate immune branch, such as monocyte/macrophages, dendritic cells (DCs), and granulocytes, constitute the first line of defense against invading pathogens.
Dendritic cells (DCs) are central regulators of the immune system that operate in both innate and adaptive branches of immunity.
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