These findings indicate that the chimeric DNA RNA hammerhead ribozyme targeting TGF-β1 mRNA inhibits neointima formation in rat carotid artery after balloon injury with suppression of TGF-β1 and inhibition of extracellular matrix and CTGF.
In conclusion, the intravenous adrenomedullin infusion effectively attenuates vascular remodeling following the arterial injury via suppression of hyperplasia in the intima and adventitia, suggesting a potential of adrenomedullin as a therapeutic tool against vascular remodeling.
HCV core protein exposure caused neuronal injury through suppression of neuronal autophagy in addition to neuroimmune activation.
Because adult cardiomyocytes possess minimal capacity to reenter the cell cycle [2], [3], limiting myocyte loss and protection of the myocyte against injury through suppression of cell death-provoking pathways represents a logical strategy to prevent heart failure [4].
The present results suggest that ginger supplement diminishes fructose-induced kidney injury through suppression of renal overexpression of macrophage-associated proinflammatory cytokines in rats.
It has been reported that TMP may provide antithrombotic effects and neuroprotection against ischemic brain injury through suppression of inflammation, blocking of calcium channels, inhibiting the formation of free radicals, and reducing the bioactivity of platelets.
Our hypotheses were that heat exposure prior to sepsis results in attenuation of lactic acidemia and that heat-exposed rats have less sepsis-induced lung injury from suppression of inflammatory response.
Lastly, intraoperative administration of the first dose may help to minimize the risk of DGF in at-risk kidney transplant recipients [ 20, 80], possibly by ameliorating ischemia-reperfusion injury through suppression of inflammatory cells and mediators as a result of leukocyte and T-lymphocyte depletion [ 81– 83], but this remains unconfirmed.
Experimental studies demonstrate that CNS injury-induced suppression of cellular and humoral immune functions contribute to the high incidence of infections [24].
