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Our models of the early onset of lung injury suggest these changes occur very early in the injurious process.
Repair after an injurious process such as VILI reabsorption of edema fluid, alveolar epithelial cell spreading and proliferation, plasma membrane wound sealing occurs in conjunction with injury [38].
Many studies implicate MMPs in the injurious process as well ALI/ARDS, which may mainly contribute to its capability of degrading all components of the extracellular matrix [60, 61].
It functions to resolve the injurious process, facilitate repair, and return the host to a state of homeostasis.
The ongoing injurious process further transforms those cells into highly aggressive invading cancer cells (Nagler et al, 1999; Nagler, 2002).
These are not ideal, fail to reflect real-time declines in glomerular filtration, and provide no data on whether a genuinely injurious process to the kidney has occurred [ 6, 59].
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Firstly, it is difficult to determine whether recovery after injury constitutes solely a repair process or whether cessation of ongoing injurious processes by cell therapy also contributes to the effect seen.
Hypoxic cell injury, hypoxia-reoxygenation injury and cold-induced apoptosis to cultured hepatocytes are in vitro models of injurious processes occurring to the hepatocyte in vivo during warm or cold ischemia and upon subsequent warm reperfusion of the liver.
Volume changes, as shown here in the hippocampus, likely result from long-term exposure to injurious processes and possibly developmental differences, whereas increased water content in the tissue could include both longer-term damage as well as acute effects.
Further studies are needed to clarify whether the drug is also able to directly counteract injurious processes like ROS production and oxidative stress.
It was proposed that hepatocyte triglyceride accumulation resulting from metabolic imbalance (obesity, IR and diabetes) is the leading factor to steatosis (the "first hit") and that the lipid-laden hepatocytes are then vulnerable to injurious processes (the "second hit") such as cytokines and oxidative stress [ 7].
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