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These data suggest that there is a possibility that some inflammatory factors contribute to APAP liver injury at an early injurious phase but that these factors might also facilitate liver regeneration at a late phase.
The injurious phase lesions may lead to dissection between the outer media and the adventitia.
The injurious phase commences with mediolysis and separation of media from adventitia [ 4].
Liver regeneration is a vital process for survival after a toxic insult, it occurs at a relative late time point after the injurious phase.
It is possible that some inflammatory factors might contribute to liver damage at an early injurious phase but facilitate liver regeneration at a late time point.
The purpose of this study was to test the hypothesis that inflammation might contribute to liver damage at an early injurious phase but facilitate liver regeneration at a late phase in APAP overdose.
Similar(53)
Some viruses exist as an antigenic stimulant in the epithelial cells of the lung in an actively replicating and potentially injurious lytic phase while other viruses persist in a latent phase for an entire lifetime.
Pathologically SAM involves an injurious and reparative phase.
Pathologically SAM involves two phases, injurious and reparative.
The embryologic role of tissue fibronectin as the initial undifferentiated matrix is recapitulated in the early phases of injurious wound healing.
Indeed, we observed an increase in the tidal volume in lungs ventilated at the higher peak inspiratory pressure/higher tidal volume (HiP groups) during the early phases of injurious ventilation, which (given the applied PCV mode of ventilation) could be translated into an increase in compliance.
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CEO of Professional Science Editing for Scientists @ prosciediting.com