I don't know if Don dabbled in Buddhist teachings while he was at that clifftop retreat center, but I've found it to be a great comfort in times of trouble, because the Buddhist masters take it as a given that we will cycle through this life, and other lives, again and again as we attempt to achieve higher states of consciousness and less injurious modes of living.
Previous studies support the concept that injurious modes of MV per se may result in release of inflammatory mediators that lead to inflammatory lung injury [ 52, 53, 59, 60].
Lung injury was induced by bronchoalveolar lavage followed by a constant, injurious ventilation mode: pressure-controlled ventilation, tidal volume 10 ml kg-1, PEEP 0 cmH2O, FiO2 1.0, respiratory rate 25 35 min-1 targeted to a carbon dioxide level < 8 kPa.
Though, the used formula does not consider, if an injurious ventilation mode leads to ongoing oedema formation.
Potential anti-inflammatory effects were not analysed, but may be equalized by the ongoing mechanical stress resulting from an injurious ventilation mode.
The combination with an injurious ventilation mode, however, should induce ongoing epithelial barrier damage and is propagated to be more similar to human ARDS [ 20, 23].
It is now well documented that inflammatory changes occur in the lung subjected to injurious ventilation modes [ 30, 31].
As a possibly less injurious and more effective mode of ventilation, CENPV appears especially attractive when the potential to eliminate endotracheal intubation is taken into consideration.
Then VILI was induced combining repeated lung lavages followed by injurious MV in Pressure Control mode with Peak Pressure=35 cmH20 and ZEEP, for one hour; then the same sequence of SRCT exposures was performed.
Indeed, we observed an increase in the tidal volume in lungs ventilated at the higher peak inspiratory pressure/higher tidal volume (HiP groups) during the early phases of injurious ventilation, which (given the applied PCV mode of ventilation) could be translated into an increase in compliance.
