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Injurious levels of strain have been observed in some capsular ligaments when loads simulating a rear-end collision were applied in-vitro [ 7, 8].
Preconditioning with a low dose of IL-1α immediately is capable of protecting the construct against subsequent catabolic destruction from exposure to injurious levels of cytokine and provides an intriguing potential for using this technique for clinical therapeutic applicability.
The authors defend this assumption with the observation that in the absence of injurious stress, the apices of subpleural alveoli undergo little to no apparent deformation, so that when they do, local stress must have reached injurious levels.
Specifically, by varying the preconditioning dose, we were able to identify conditions under which mechanical properties and biochemical composition were significantly retained, despite subsequent exposure to injurious levels of the cytokine, even when the insult is delayed.
In the mammalian lung, repair of the alveolar epithelial cells after pressure was increased to injurious levels and then lowered to non-injurious ones was reported by Vlahakis et al. (Vlahakis et al., 2002).
With relatively mild genotypes, the A2PE and its derivative A2E do not accumulate to injurious levels in the photoreceptor cells but instead accumulate in the underlying retinal pigment epithelium (RPE) as a result of the normal phagocytic turnover of the outer segments.
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If sepsis is a manifestation of a nonlinear dynamic control system operating at an excessive and injurious level, then filtration at modest doses with a large pore filter may succeed; high-volume hemofiltration with a conventional MWCO should also be effective.
Briefly, constructs were allowed to elaborate a threshold amount of ECM (attaining a EY of at least 100 kPa), exposed to a low-dose concentration of IL-1α for 7 days and then subjected to an injurious level of cytokine for the final 7 days.
Furthermore, the data did not exclude a reduction in inflammation as the primary mechanism of neuroprotection again without achieving discrimination whether the amelioration of injurious intracellular axonal levels of Na+ and Ca2+ were the targets of amiloride treatment.
These types of definitions ranged from single sentences including a variety of symptoms (e.g. bruises, strains, cuts and abrasions, back pain and fractures [ 49, 50]) regardless of severity to multiple-level definitions categorising injurious falls according to five levels of severity (from no injury [level 0] to broken bone [level 4] [ 67]).
This was supposed to be a column about the NFL's punishment of New Orleans Saints' coaches and players for their role in running a bounty program in which players were paid to level injurious hits on opponents.
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