Evzio, which gained approval by the Food and Drug Administration in 2014, is an "automatic injector" that guides its users through the steps of treating an overdose victim via voice instructions.
Drugs were delivered using a microinfusion pump (Harvard Apparatus, Holliston, MA) connected to a 33-gauge microsyringe injector, via indwelling guide cannulae.
The injector remained in the guide cannulae for a further minute following administration in order to allow adequate diffusion of the injectate into the PVT.
In this paper, several current voltage scaling laws are summarized for guiding the injector design.
The injector for the 22 AWG guide cannula was a 28 AWG cannula that extended 1.5 mm below the bottom of the guide cannula.
Substances were administered into 3v via a stainless steel injector (30 gauge) through the guide cannula.
From these results, the system demonstrated sufficient accuracy to guide the micro-injector from the planned delivery routes into practice.
(1) syringe pump, (2) injector valve, (3) switch valve to guide the sample to the desired channel, (4) tubing for inlet, (5) outlet, (6) poly methylmethacrylate) plate, (7) Pt counter wire, (8) Ag/AgCl reference wire, (9) polydimethylsiloxane channels, (10) pyrolytic graphite chip (black), surrounded by hydrophobic polymer (white) to make microwells.
The injector was introduced within the ICV guide prior to the beginning of a recording session which lasted 30 min.
Injectors were placed into the relevant guide cannula and extended 1.5 mm past the end of the guide, into cortex.
