Parameters assessed for 80 minutes after drug injection (single bolus dose) were pain on injection, involuntary movement, BIS, blood pressure, need for airway support, and, as measures of recovery from sedation, the Richmond Agitation and Sedation Scale and the Digit Symbol Substitution Test.
The present study measured the response of vitamin A depletion mice and normal mice to the injection of single dose of MK-801 (0.6 mg/kg).
Besides, "accelerated blood clearance phenomenon" was found through evaluating blood clearance profile of CBSA-NP post-injection of single dose or over a period of successive high doses of CBSA-NP.
Nanotechnology is also enabling highly efficent radiotherapy, such as the injection of single doses of an atomic nanogenerator at kilobecquerel (nanocurie) levels into mice bearing solid prostate carcinoma or disseminated human lymphoma induced tumour regression and prolonged survival, without toxicity, in a substantial fraction of animals (McDevitt et al, 2001).
scVEGF/177Lu or scVEGF-PEG-DOTA (5 6 μg/mouse) were delivered in 50 μl via retro-orbital sinus injection and a single dose of Doxil (1 mg/kg body weight) was delivered in 100 μl via tail vein injection.
Upon injection of a single dose of LPS/GLN, 90% of wild-type (WT) mice died within approximately 6 8 h after injection, but CerS2 null mice were completely resistant.
The first group (#1) of 5 male and 5 female mice was treated with a single IM injection at a single dose.
These mice received either an intraperitoneal saline injection or a single dose of 15 mg/kg carboxymaltose ferric at week 1 (ID+I and CT+I groups).
The hyperglycemia were induced by intraperitoneal injection of a single dose of streptozotocin (STZ, 240 mg/kg body weight, from Sigma chemical Co., St . Louis Mo) diluted in phosphate-buffered saline pH 7.2 (Oyama, Sugimura, Murase, Uchida, Hayasaka, et al., 2009).
H69- or CA20948-xenografted mice with tumour volumes of approximately 120 mm3 were euthanized at 10, 30, 60 and 120 min post injection of a single dose of 213Bi-DOTATATE (1.5 4.8 MBq).
