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For the signal used in Fig. 4A, the mitral cell was stimulated by injection of a current pulse through a patch clamp electrode to generate a series of action potentials.
Simulation of EPSPs were performed using somatic injection of a current with an exponentially rising and falling waveform: f(t) = a·((1 - exp(- t/τon))·(exp(- t/τoff)).
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In the 1930s, Marcel and Conrad Schlumberger pioneered an EM field survey that relied on naturally occurring telluric currents rather than on the active injection of a direct current by a pair of electrodes (Schlumberger 1939).
But what difference does it make if a perturbing current is generated by a mini-epsp or ipsp, or the closing or opening of a channel, or injection of a brief current pulse through a microelectrode?
The latter two are also spontaneously active (implemented via the injection of a constant current of 0.1 nA in the model).
The role of "synaptic" or "intrinsic" noise in spike timing was investigated by the injection of a fluctuating current in two different configurations: one during the 200 ms immediately preceding the synchronized compound EPSC onset (pre-noise case) and another, starting 200 ms before and continuing during the presentation of the EPSC (noise case) (Figure 5A).
On further injection of a depolarizing current, cells from both genotypes showed tonic firing of action potentials.
Producing a high B p leads to the heating of the B p coil due to the injection of a high current.
Then, this visual stimulus was paired with one or a few APs evoked by injection of a step current (15 ms, 1010 ± 102 pA).
In order to study the range of firing patterns accessible with the AdEx, we simulate the injection of a step current.
Injection of a negative holding current was followed by an increasing positive current pulse from 0 to 8 nA that did not affect the amplitude or shape of action potentials (Fig. 4A), indicating saturation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com