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The results of this study may be helpful for clinicians to determine an intravitreal bevacizumab injection dosing regimen for ME secondary to BRVO.
For i.v. injection, dosing solutions were delivered using a 1 mL syringe into the femoral vein (a cannula was inserted for injection).
In this context, an injection dosing system (conceptual design, laboratory evaluations and analyses) has been developed to perform liquid injection synchronised with soil punching and variable rate application.
This study examined 2 different intravitreal bevacizumab injection dosing schedules in patients with ME secondary to BRVO.
Second, a small number of patients were included in this study, and only 2 intravitreal bevacizumab injection dosing schedules were compared.
Previous studies evaluating various dosing regimens have shown the efficacy of bevacizumab for treating ME due to RVO [ 15, 19, 21– 23]; however, an optimal bevacizumab injection dosing schedule has yet to be determined.
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The use of post-reconstruction filter significantly reduced CV values at all the injection doses tested.
The injection doses used in this study are similar to those in other studies.
Injection of the IMP will be followed by intravenous GCV injection dosed according to the manufacturer's recommendation, which will be at 5 mg/kg b.i.d.
Thus, the maximum injectable activity is 537.6 MBq [18F]FACT/year, and this injection dose limit allows two or three PET scans to be performed.
(a) Cocaine injection dose and injection paradigm used.
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