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There are several possibilities to explain the observed distance deviation between the 99mTc-nanocolloid injection depot and the 125I seed on SPECT/CT.
In the following 36 125I seeds (34 patients), the average difference between the 125I seed and the centre of the 99mTc-nanocolloid injection depot was 10.9 ± 6.8 mm.
In these patients, additional SPECT/CT was acquired to measure the distance between the 99mTc-nanocolloid injection depot and the 125I seed.
Retrospective analysis of the data showed a possible relation between the number of measurements made by the freehand SPECT and the distance between the 99mTc-nanocolloid injection depot and the 125I seed.
The ten injections with more measurements resulted, after measuring the distance between the 99mTc-nanocolloid injection depot and the 125I seed, in a mean distance of 10.0 mm instead of 11.2 mm in the other 26 injections.
In the retrospective study, the average distance between the 125I seed and the centre of the 99mTc-nanocolloid injection depot as measured in SPECT/CT was 9.7 ± 6.5 mm and was not significantly different compared to the freehand SPECT-guided group (two-sample Student's t test, p = 0.52).
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This group is selected to study the US-guided injection depots of 99mTc-nanocolloid by means of SPECT/CT without making additional SPECT/CT scans.
Contraceptives used were: oral contraceptives – 35%, injections (depot medroxy progesterone acetate (Depo-provera) – 10%, Intrauterine devices – 2%, combinations of these and tubal ligation – 30%.
Long-acting injection (LAI, depot) antipsychotic formulations are recommended for the treatment of non-adherent patients [ 13], as depot medications ensure adherence during the injection duration and may help reduce the risk of relapse [ 14- 16].
Injection of depot methylprednisolone into the greater and lesser occipital nerve region produced complete headache relief for a period of 10 77 days [9].
Significantly, a single injection of depot forming GLP-1-ELP fusions reduced blood glucose levels in mice for up to 5 days, 120 times longer than an injection of the native peptide.
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