During the NSW Supreme Court trial, the jury heard Dank had instructed Mannah that injecting peptides was safe.
Antisera against GlgP slr1367) and PhaA were produced by injecting peptides NH2-EIIHNEKNQPK-COOH or NH2-CDGLTDSTNGEGMGEQ-COOH, respectively, into rabbits.
However, such a comparison is not fully conclusive since these therapy studies differ in tumour size at the beginning of therapy, injected peptide amount, administered radiation dose and injection interval.
Accumulation of radioactivity in the kidneys was in the range of ~6.6 % IA/g to ~9.1 % IA/g, 5 h after injection of 177Lu-DOTANOC, independent of the molar amount of injected peptide.
The optimal mass of injected peptide was found to be 0.3 nmol.
Renal uptake of the PP-F11 peptide is hardly influenced by the injected peptide mass, contrary to the tumour uptake.
The mass of injected peptide influences the pharmacokinetics (PK) and absorbed doses in organs and tumors [6].
Organ uptake of 0.03 3 nmol mass of injected peptide are indicated in Additional file 1: Tables S2 S6.
Additional experiments were conducted to investigate the influence of the injected peptide amount (0.5, 2.5, and 5.0 nmol, respectively) on the tissue distribution of the radiopeptide.
Therefore, the mass of injected peptide should be optimized to deliver efficacious tumor doses while avoiding toxic absorbed dose to organs, especially to the dose-limiting organs the kidneys and bone marrow [7, 8].
