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Most of the drugs in short supply are sterile injectables that have been cheap mainstays for decades.
An addiction to plastic surgery led to a nose job, multiple liposuction procedures and injectables that were certain to generate attention -- and they did.
13, 14 ACTs have been free in Laos for all ages in the public sector since 2005, and artemisinin-based monotherapies have been withdrawn since 2008, except artesunate injectables that are, as recommended by WHO, the optimal treatment of severe malaria.
TasP, PrEP, microbicides, and PEPSE are better understood as biobehavioral interventions as they are all user dependent, whether they are pills that need to be taken at a certain frequency, microbicide gels or rings that need to be inserted and left in situ for specified periods, or injectables that require clinic attendance at particular intervals.
If only 1 of 5 sub-Saharan African women now using pills or injectables (that is, other, less effective hormonal contraception) were to switch to an implant, more than 1.8 million unintended pregnancies would be averted in 5 years, resulting in almost 600,000 fewer abortions and 10,000 fewer maternal deaths.
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The UN AIDS conference has just discussed the first results of a long-acting injectable that could transform PrEP from daily pill-taking to three monthly injections.
The 50 50 (n/n) copolymer system, composed of L-lactic acid and L,D-2-hydroxyoctanoic acid, is a viscous injectable that will form an intravitreal drug depot.
Development of a longer-acting injectable that could provide at least 6 months of pregnancy protection is currently underway.
One intradermal animal study (Sasaki et al 2003) with hylan (Synvisc), a chemically-modified hyaluronic acid injectable that is widely used to treat knee pain associated with degenerative osteoarthritis, resulted in severe foreign body-type granulomatous inflammation in guinea pigs.
In a recent human study using a particulated biphasic calcium phosphate (BCP) either or not with EMD, graft exfoliation was not described; this might be due to differences in the used grafting materials; particulated versus injectable that needs to set in situ.
It's easier to give even an injectable that they're accustomed to delivering than cells because they're different.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com