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The Women's Health Initiative trial reports an excess of heart disease in postmenopausal women receiving MPA.
During the development of WISDOM the Women's Health Initiative trial was designed, funded and started in the US.
In the more recent DO-RE-MI (DOse REsponse Multicentre International Collaborative Initiative) trial [ 7], even higher peaks of downtime duration were reported (up to 28%).
3 4 The perception of the risks and benefits of HRT and its timing has changed dramatically since the publication of the women's health initiative trial in 2002.
In the INITIATIVE trial, visual symptoms were reported by 16.3% of patients receiving ivabradine 7.5 mg twice daily and 5.6% of those in the atenolol 100 mg once daily group (Tardif et al. 2005).
44, 45 For example, in a study of postmenopausal women recruited to a Women's Health Initiative trial with or without osteoporosis, calcium plus vitamin D supplementation increased hip bone mineral density.
Similar(49)
Also, after censoring follow-up at July 2002 (to coincide with publication of the first results from the women's health initiative trials 27), significant differences between the effect of transdermal therapy and oral therapy persisted.
This analysis included all 161 808 women enrolled in the women's health initiative clinical trial (68 132) or observational study (93 676).
The HRT was considered the most common choice for the treatment of menopausal symptoms until the publication of Women Health Initiative (WHI) Trial, in 2002.
The Preexposure Prophylaxis Initiative (iPrEx) trial [ 13] and others [ 14– 16] demonstrated the efficacy of once-daily oral emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) in preventing HIV acquisition.
iPrEx (Pre-exposure Prophylaxis Initiative), a trial of oral Truvada as PrEP in MSM, demonstrated a 44% reduction in HIV incidence in MSM who were taking PrEP compared to control subjects.
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