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The left side of the above equation is the overall effect of treatment during time from treatment initiation to time of efficacy assessment, and can be denoted as TR.
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Progression-free survival was defined as the time from drug initiation to the time of disease progression, or death, or was censored at the last follow-up.
The progression-free survival (PFS) was defined as the period from the time of therapy initiation to the time of disease progression or death.
The cumulative dose of each medication was defined as the accumulated area under the curve (AUC) from the time of drug initiation to the time of LSM during the interval follow-up days (see Additional file 1).
Disease-free survival was estimated from the date of the first day of CRT initiation to the time of documented failure (local recurrence or metastasis occurrence) or the date of the last follow-up for those remaining with CCR.
In addition, we used the time of documented hypotension, rather than vasopressor initiation, to identify the time of septic shock recognition.
As replication timing maps are population averages, assigning an initiation to a particular time (the midpoint of the probability distribution of initiations for that origin) is an approximation.
Overall survival time was defined as time from initiation of treatment to time of death or last follow-up.
Due to low number of observations we were not able to disentangle PMH initiation in relation to time of menopause.
We sought to examine the association between antihypertensive class and incident non-vertebral fractures among older adults initiating monotherapy according to time since initiation.
Sixth, and finally, in the time to event approach, patients can naturally contribute repeated episodes to the analysis (eg time to first initiation, then time from initiation to cessation etc).
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