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Treatment targets for BG will be preprandial values of 4 7 mmol/L and postprandial values of <10 mmol/L according to the Danish guidelines for the treatment of T1D. 25 At randomisation, the insulin dose will be reduced by 33% for the bolus and 25% for basal insulin before study drug initiation to reduce the risk of hypoglycaemia.
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However, there may be situations where extraordinarily high levels of Bcl-2 and/or Mcl-1 impair the ability of translation initiation inhibitors to reduce these to levels sufficient to trigger an apoptotic response.
Snowball sampling, with multiple initiation points to reduce selection bias, was necessary to locate and identify participants, provide reassurance and break down barriers.
Initiation of treatment to reduce acid secretion with proton pump inhibitors should also be started to try to decrease spillage of acidic fluid into the abdomen.
Modification of translation initiation regions (TIRs) to reduce protein translation rates has also had some success at improving overall yield [12].
Timing of ART initiation is critical to reduce IRIS-associated morbidity.
When aligning to motion onset, the time period within 100 ms before saccade initiation was excluded to reduce contamination of the averages with peri-saccadic activity.
In patients who were not indicated for thrombolytic therapy, early initiation of treatment to reduce secondary neuronal damage is required for a favorable outcome.
A better understanding of the critical alterations implicated in tumor initiation is necessary to reduce the mortality rates through early diagnosis and treatment.
The need to pay attention to rapidly changing weights and drug dosing based on multiple parameters, such as weight and gestational age, as neonatal prescribing requires vigilance both at dose initiation and maintenance to reduce medication errors.
These findings suggest that an earlier start of active tracing of patients that missed a scheduled visit date, especially when loss to follow occurred shortly after ART initiation, may help to reduce early mortality.
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