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This is an excellent comment from the reviewers and indeed, we admit that we did somewhat "shy away" from fully discussing this issue in our initiation submission.
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We did not include this data in the initial submission, as we felt that it does not strengthen the core findings of this manuscript that is focused on the initiation of exploratory filopodia from dendrites.
It all begins with the submission of a Project Initiation Form (PlF) to the SPMO.
The submission of certificates at the initiation of a session allows the parties to know who it is they are about to communicate with.
The focus on study startup, a slow and inefficient phase at the outset of trials, is intense when companies have to wrestle with country selection, pre-study visits, site selection and initiation, contract and budget execution, regulatory document submission and enrolling subjects.
The study startup phase is where this happens, and it includes such activities as site and investigator selection, regulatory and ethics submissions and ends with the site initiation visits and release of the investigational product (i.e., the drug under investigation).
The median time to tracing and initiation of appropriate anti-tuberculosis treatment from time of specimen submission in these children was 2.5 months (range 0.3-15 0.3-15 months
Randomized efficacy trials take approximately 5.5 years from the initiation of enrollment to publication [1], and 7 years or longer after adding the time from grant application submission to enrollment initiation.
* submission.
In submission.
Inflorescence initiation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com