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Collectively, these results indicate that Xrn1 is required for efficient translation of RNA2, likely at early events of the translation initiation step.
The initiation step relies on the interaction of trans-acting factors (initiators) with cis-acting DNA sequences (replicators or origins).
One such strategy is targeting the initiation step of the complement activation and blocking each of the 3 initial pathways separately [54].
Comparative study of the radical initiation step.
Translation can be modulated by a myriad of factors and control mechanisms that target either the initiation step or a post-initiation event.
Bernstein, E., Caudy, A. A., Hammond, S. M. & Hannon, G. J. Role for a bidentate ribonuclease in the initiation step of RNA interference.
After the transcription initiation (step 1), DSIF (Spt4 Spt5) is recruited to Pol II, while P-TEFb phosphorylates the Pol II CTD (step 2).
This suggests a common role for Xrn1 in regulating translation of cellular mRNAs and BMV RNA2, likely at the translation initiation step.
MALDI-TOF analysis of polycarbonates was used to investigate the initiation step of the copolymerization.
Our data suggest that ceramides directly regulate a key initiation step in apoptosis: mitochondrial outer membrane permeabilization (MOMP).
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For each population, potential indications are initiation, step-up of current drug therapy, and straight substitution of individual drug components.
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