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This translation initiation signal directs the ribosomes to initiate protein synthesis from mRNAs.
The initial plasmid pJOE4056.2, which already bears a well-working translation initiation signal of T7 gene 10 and the transcription terminator from the rrnB operon, has been mainly improved by insertion of a stem loop and by deletion of one cer site.
The expression data presented reflect a tightly controlled transcription initiation signal in response to cyclohexanone.
A central paradigm can be recognized in most events of cellular signaling, which consists of three distinct steps: signal initiation, signal transduction, and gene activation.
Application of this model to a test set of core promoters not only gave better discrimination of potential promoter sites than previous statistical or neural network models, but also revealed indirectly subtle properties of the transcription initiation signal.
iOPN, which lacks the signal sequence that targets the protein to secretory vesicles, possibly due to a down-stream alternative translational initiation signal, is expressed in dendritic cells and macrophages of the immune system [12].
Similar(24)
Identifying regeneration initiation signals remains a key challenge in regeneration research.
However, fundamental questions about the nature of regeneration initiation signals have remained unanswered.
In the first model, regeneration occurs solely after R-wounds because they are the only wound type in which regeneration initiation signals are induced.
The two main mechanisms that expand the proteomic output of eukaryotic genes are alternative splicing and alternative translation initiation signals.
Answering this fundamental question has important implications for regenerative medicine: depending on which hypothesis is more accurate, providing damaged tissues with initiation signals may or may not be sufficient for promoting regenerative processes.
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