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A varying number of images were acquired per run owing to the self-paced initiation of trials.
The existence of rare but exceptional results with immunomodulators in metastatic patients triggered initiation of trials testing these drugs, combined or not with antineoplastic agents in the adjuvant setting.
In order for gene expression profiling to be useful, the initiation of trials evidently needs to keep pace with the introduction of new treatments that are shown to be best practice.
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The T3 and T4 ewes were vaccinated at D1 (initiation of trial) and D10, while the T4 ewes were additionally administered the EP dried roots.
It provides a tool by which subjects can be identified as symptomatic prior to the initiation of trial treatment.
A platinum therapy free interval of ⩾6 months was required prior to initiation of trial therapy.
Patient consent must be obtained prior to the registration or initiation of trial procedures.
This could be achieved by staggering initiation of trial sites and targeting sites with known experience or expertise.
At 3 years after initiation of trial therapy (a follow-up time which all patients reached), 27 patients (36%) were alive and tumour free (cured).
Prior to the initiation of trial activities, the project team undertook a community mapping and household enumeration exercise to delineate the CHW surveillance areas that served as the clusters for this trial.
"The current transition of the leprosy vaccine from the preclinical to the clinical testing phase has necessitated a large amount of due diligence and care in manufacturing, which precludes initiation of safety trials in a small number of individuals," Duthie explains.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com