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HNF6 controls the initiation of the expression of pancreatic and duodenal homeobox 1 (Pdx1), the earliest marker of pancreatic precursor cells [ 67].
BTPC is significantly expressed in the pollen of both Arabidopsis and lily, but the initiation of the expression of each BTPC differs during pollen development.
These studies have lead to the understanding that during myofibrillogenesis, the initiation of the expression of the many proteins involved occurs in an ordered sequence, suggesting a specific impact of the individual proteins in the complex mechanisms associated with sarcomere formation [ 4].
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Elucidating the cellular and molecular mechanisms that regulate initiation and termination of the expression of these differentiation factors will be important for understanding the developmental programs in these tissues.
HSF1 has been described to have an important role in carcinogenesis as shown by its role in tumour initiation and progression through the regulation of the expression of Hsps and other targets [ 171, 172].
After initiation of differentiation, the expression of miR-133 is upregulated.
With the initiation of dedifferentiation, the expression of type II collagen and aggrecan declines gradually, and the expression of type I and type III procollagens is induced instead.
Four months following initiation of treatment, the expression of most of the above mRNAs was attenuated, and expression of CD40L, IFN-α and IL-22 remained undetectable.
Deregulation of the expression of DNA replication-initiation proteins results in genomic instability and contributes to the malignant transformation of cells [ 3].
DOI: http://dx.doi.org/10.7554/eLife.10874.004 While the large majority of nonpeptidergic-specific genes require both NGF and Runx1 for initiation of expression, expression of the nonpeptidergic marker Ret displays differential dependence on NGF and Runx1.
The initiation of MTS affects the expression of multiple proteins.[22] [24] The identification of proteins that are characteristic of metastasis might allow the discrimination of different tumor entities.
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