After initiation of the baseline stability period, the bone marrow transplantation laboratory thaws and washes the human MSCs.
At the first available time point for immunological studies and before initiation of HAART (baseline, BL), all investigated subjects showed a positive, and in most cases robust, HIV-specific CD4+ T cell response (median total response 2,780 SFC/106 CD8-depleted PBMCs; range 315-8646) (Figure 5A).
All patients had adenomas at the initiation of treatment (baseline) and showed adenoma regression after 6 months treatment with sulindac.
Two serum samples were collected for bone markers, 1 week apart, prior to initiation of therapy; baseline levels were the average of these two values.
In the present study, we used plasma samples obtained before the initiation of treatment (baseline) and after 6 months of treatment.
Data were collected retrospectively 6 months before the start of cinacalcet, at initiation of cinacalcet (baseline) and retrospectively or prospectively (depending on the time of enrolment) for the next 12 months.
ART coverage had expanded dramatically from 9 sites in 2003 to over 550 sites (67 private sector) at the time of initiation of the baseline study in October 2011, with over 275,000 HIV-positive individuals alive and on treatment [ 31].
The following demographic data were recorded at the initiation of treatment (baseline, week 0): disease duration, concomitant treatment (methotrexate (MTX) or prednisolone (PSL)), joint damage (Steinbrocker stage), and daily dysfunction (Steinbrocker class).
The following demographic data were recorded at the initiation of treatment (baseline, week 0): disease duration, concomitant treatment (methotrexate [MTX] or prednisolone), joint damage (Steinbrocker stage), and daily dysfunction (Steinbrocker class).
