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Treatment success was defined as absence of fever 72 hours after initiation of antibiotic therapy.
To identify factors associated with timely initiation of antibiotic therapy for patients hospitalized with pneumonia.
Initiation of antibiotic therapy was left to the clinician's appreciation.
Recent rapid PCR-based techniques provide information allowing prompt pathogen identification even after initiation of antibiotic therapy.
An abundant literature is available on PCT-guided initiation of antibiotic therapy in patients suspected clinically of having LRTI, providing a high-level of evidence.
Few have studied the value of serial measurements in the assessment of VAP, either before the diagnosis or after initiation of antibiotic therapy.
Immunofluorescence staining of pneumococci demonstrated the presence of bacterial capsules in the meninges of all meningitis patients, even 35 days after the initiation of antibiotic treatment.
Blood cultures were taken 3 days after the initiation of antibiotic therapy due to logistics in North Greenland and were, as could be expected, negative.
Biomarker-guided initiation of antibiotic therapy has been studied in four conditions: acute pancreatitis, lower respiratory tract infection (LRTI), meningitis, and sepsis in the ICU.
Regarding our results, attention should be paid to patients whose ICU stay is extended and to patients in whom bacteriological samples were positive to Pseudomonas aeruginosa if diagnosed before the initiation of antibiotic therapy.
The presence of pneumococcal capsule in CSF and brain up to 35 days after initiation of antibiotic treatment may be suggested to be a source for an ongoing (or resurging) inflammatory response.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com