Sentence examples for initiation of a large from inspiring English sources

In the highly nonlinear phenomena involved in earthquake generation, there may be a threshold value of the strain that must be exceeded prior to initiation of a large earthquake..

The study supports the initiation of a large scale study on the effect of Paleolithic diet in subjects with type 2 diabetes.

Promising results from a small case series on sorafenib combined with fotemustine 20 led to initiation of a large phase II study of sorafenib the results of which are still pending.

However, the detected pattern of the time course in the differences between groups, suggesting a biologically meaningful effect, is encouraging and supports the initiation of a large prospective controlled trial in light of its importance for public health.

A placebo-controlled pilot study showed that CEP-1347 wasafefe and well tolerated by PD patients (Parkinson Study Group 2004b), and this supported the initiation of a large trial of longer duration with CEP-1347: the PRECEPT study (Parkinson Research Examination of CEP-1347 Trial).

Side effects were minimal and consisted mostly of ulceration of the vaccination sites caused by the BCG adjuvant.These promising results prompted the initiation of a large phase III study of stage II/III colon cancer patients conducted under the auspices of the eastern cooperative oncology group (ECOG) [ 20].

The initial success of the studies in animal models of diabetes and of a pilot trial in relatives of patients with T1D (which demonstrated that insulin given before disease onset prevents or delays diabetes) led to the initiation of a large-scale clinical trial of an antigen-based therapy for the prevention of diabetes [ 22– 22].

The simplified multiscale concept, consisting of a small patch and a large patch, has been applied to the discussion of full seismic cycles under the rate- and state-dependent friction law, with a particular focus on how small heterogeneities can affect the initiation process of a large earthquake (Noda et al. 2013).

This led to the initiation of a much larger multicenter RCT to compare two targeted temperature regimens (mild hypothermia of 33 °C versus near normal body temperature of 36 °C) in 939 unconscious survivors of OHCA of presumed cardiac cause after sustained return of spontaneous circulation.

These results together demonstrate a general requirement of both NGF and Runx1 for initiation of expression of a large subset of nonpeptidergic neuron genes.

We conclude that NGF and Runx1 are both required for initiation of expression of a large cohort of nonpeptidergic nociceptor-specific genes, with Ret being a notable exception.