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In recent years there has been a 4-5% annual increase in initiation enrolments nationally.
From 2005 to 2006, 78 (12.7%) participants diagnosed with HIV infection before study initiation delayed enrolment by 6 months to 1 year.
This study was registered (ClinicalTrials.gov, unique identifier NCT01330238) prior to the initiation of enrolment and was conducted in accordance with the principles of the Declaration of Helsinki.
All participants provided written and informed consent prior to study initiation and patient enrolment.
Ethics approval for the trial has been obtained from the Princess Alexandra Hospital Human Research Ethics Committee prior to study initiation and patient enrolment.
Ethical approval for trial has been obtained from Nottingham Ethics Committee for all participating centres prior to study initiation and patient enrolment.
Ethics approval for the Omega-3 fatty acids (Fish Oils ) and Aspirin in Vascular access OUtcomes in REnal Disease (FAVOURED) trial was obtained from local Human Research Ethics Committees in all participating centres prior to study initiation and participant enrolment.
Ethics approval for the HEMe iron polypeptide Against Treatment with Oral Controlled Release Iron Tablets trial (HEMATOCRIT trial) has been obtained from the local Institutional Ethics Committee in all participating centres prior to study initiation and patient enrolment.
The number of participants enrolled at each site in this period ranged from zero sixx sites) to 18 (one site), but the initiation of screening and enrolment was staggered across the participating sites because of variability in the time required to obtain ethics approval and negotiate institutional contracts (Table I).
The median time from pre-ART enrolment to ART initiation was 16 days (IQR, 5 101).
Time from enrolment to treatment initiation decreased (P < 0.001).
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