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A data reduction scheme was used to estimate crack initiation cycle.
Crack growth rate (da/dN) measurements along the width, thickness and the striation ridge lines indicated that the latter provides the most reliable results in terms of estimating fatigue crack initiation cycle, crack initiation site, and crack growth rate.
Patients were evaluable for the cohort if they completed 90% of their expected dose of HCQ for the initiation cycle.
The 6 wk of RT and TMZ (chemoradiation) plus a 4-wk rest period was considered the initiation cycle.
During the initiation cycle a complete blood count was performed weekly or more often if grade 3 or 4 myelosuppression was observed.
Before accrual to the next dose level began, all patients in a given cohort completed the 10-wk initiation cycle, permitting toxicities to be assessed (DLT period).
Similar(52)
Plates were run on a Roche LightCycler 480 platform, using the following thermal cycling program: activation for 10 min at 95°C; two initiation cycles of 15s at 95°C followed by 15s at 49°C; 35 amplification cycles of 15s at 95°C, 10s at 60°C and 15s at 72°C.
The crack initiation cycles reduces with an increase in normal stress keeping axial stress amplitude at a constant value.
Also the crack initiation cycles reduces with an increase in axial stress amplitude keeping normal stress at a constant value.
Beneficial effects of the compressive residual stresses on the total fatigue lives and crack initiation cycles are investigated by using the numerical simulations and experimental tests.
It appears that mutations altering the initiation site for minus strand synthesis interfere with the proper transfer of the nascent DNA strand to the 3' end of pregenomic RNA and, as a consequence, induce one or more "slippage-initiation" cycles before the transfer finally occurs.
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