Sentence examples for initiation capacity from inspiring English sources
For example, Notch-GFP reporter system has been used to separate CSCs from lung adenocarcinoma and breast cancer, GFP+ cancer cells could differentiate into GFP− cancer cells, and have strong tumor initiation capacity (D'Angelo et al., 2015; Hassan et al., 2013).
The next experiments tested whether the tumor initiation capacity could be propagated in vivo.
For example, the clonal expansion and xenograft initiation capacity of CD44+-selected colorectal cancer CSC could be inhibited by CD44 knockdown [25].
Given the strong translation initiation capacity of TISU, it is likely that in these genes it competes with the downstream AUG, and behaves as a strong inhibitor of translation.
Interestingly, cells that express both ALDH and CD133 possess greater tumor initiation capacity [ 34].
This model was verified by stem cell marker expression, tumour initiation capacity and chemotherapeutic resistance.
Initiation capacities, however, seem to be correlated with formation of nonacetylated, arylamine adducts.
Our results in the MDA-MB-231 xenograft model do not show additional benefit over chemotherapy in terms of tumor volume; however, it is clear that the benefits of L-NMMA lin in the ability of this inhibitor to reduce self-renewal and tumor initiation capacities of CSCs.
Both compounds induced TIC death at nanomolar concentrations in vitro, significantly reduced NB xenograft tumour weight in vivo, and dramatically decreased self-renewal or tumour-initiation capacity in treated tumours.
Recent studies have shown that CSCs are a small subpopulation of tumor cells that possess self-renewal and tumor-initiation capacity and the ability to give rise to the heterogeneous lineages of malignant cells that comprise a tumor [ 2].
Meikle et al. [ 13] reported that, under grazing conditions, lean cows with reduced serum IGF-1 concentrations presented prolonged postpartum anestrus, showing that circulating IGF-1 levels are good indicators of the re-initiation capacity after calving, which is in accordance with others [ 45, 46].
