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According to the CSC hypothesis, tumor cells exist in a hierarchy with a select population, that is, CSCs or tumor-initiating cells, being responsible for initiation and recurrence of tumors.
We show effective nonviral DNA delivery to human primary brain tumor initiating cells (BTICs), thought to contribute to tumor initiation and recurrence.
Since CSCs contribute to cancer initiation and recurrence after conventional therapy, they may be a potential detection index.
To investigate CSC properties such as tumor initiation and recurrence, many studies have examined methods for isolation of CSCs from cancer specimens or cell lines.
The authors also discuss advances in defining epigenetic mechanisms controlling GBM initiation and recurrence and the drug discovery considerations associated with targeting epigenetic enzymes for GBM treatment.
We also discuss advances in defining epigenetic mechanisms controlling GBM initiation and recurrence and the drug discovery considerations associated with targeting epigenetic enzymes for GBM treatment.
Similar(48)
Tumour-initiating cells (TICs) play a pivotal role in cancer initiation, metastasis and recurrence, as well as in resistance to therapy.
In particular, we consider the specific roles of elevated extracellular glutamate and K+ in the initiation, propagation and recurrence of spreading depolarizations.
Several studies suggest that the initiation, progression, and recurrence of gliomas are driven, at least partly, by cancer stem-like cells.
The contribution of genetically engineered mouse models to our understanding of tumor initiation, metastasis and recurrence will be reviewed as will non-invas veimaging approaches to visualizing quantifiable aspects of tumor biology in these models.
Tumor-propagating cells (TPCs) are believed to drive cancer initiation, progression and recurrence.
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