The near-complete sustained depolarization above the inactivation threshold for action potential generating channels initiates spreading depression of brain activity.
The finding that talin1-depleted HUVEC can initiate cell spreading on plastic or glass surfaces in the presence of serum is consistent with the report that talin-depleted cells can initiate spreading on fibronectin but that this spreading cannot be maintained in the absence of talin (Zhang et al., 2008).
Established cancer cell lines demonstrating high tumorigenicity in xenograft models may capture some properties of cancer cell subpopulations that are responsible for initiating and spreading the tumors.
It operates to establish an 'access field' which is considered a necessary step for initiating a spreading activation process that underlies stimulus recognition.
Those BS cultures were initiated from spreading onto MEA a large number of basidiospores, which were collected by placing the pileus of T0984 on a sterilized plate for several hours, allowing basidiospores to fall from gills.
A subculture was initiated by spreading conidia and hyphae onto 47 mm nitrocellulose membranes (0.45 μm pore size, Whatman, Maidstone, England), which were overlaid onto PDA plates.
Spheroids were pooled to the centre of the well and cultured for a period of 24 h to initiate their spreading.
To initiate cell spreading, a cell must prevent or disrupt skelemin binding to allow for the recruitment of other proteins to integrin clusters that facilitate cell spreading, such as talin and Src.
Cell adhesion is not simply a function of the affinity of integrin to its ligand, but involves post-receptor-binding events that regulate receptor avidity and initiate cell spreading.
In this model, the RNP1 motif initiates the spreading of the immune response to the whole protein (intramolecular spreading), then proceeds in an ordered manner to other proteins containing the RNP1 motif, and finally, to proteins that do not contain any RNP1 motif but are colocalized in the same particle (intermolecular spreading).
