Sentence examples for initiating properties from inspiring English sources

This observation echoes those recently reported in adult glioma tissues [52] and in adult glioblastoma-derived TSCs [49], [53], and lends credence to the view that brain TSCs could be characterized by the unique association of a neural stem cell profile and of a mesenchymal profile essential for maintaining the tumor initiating properties of the cells [49].

Herein, we present the new hypothesis that metformin might function as a tissue sweeper of pre-malignant cells before they gain stem cell/tumor initiating properties.

Its pertinence as a glioma stem cell marker is now highly controversial, several groups having demonstrated the tumor initiating properties of CD133- cells [ 27].

In addition to preferential expression of ALDH1 in breast cancer cells with tumor initiating properties [ 25], retinoid signaling has been directly implicated in modulating breast cancer stem cell (CSC) differentiation [ 37].

Here, we show that a previously developed DNA crosslinked hydrogel circumvents the need of environmental factors and undergoes controlled stiffness change via DNA delivery, a feasible approach to initiate property changes in vivo, different from previous attempts.

In this study, primary human breast tumor cells were evaluated for tumor-initiating properties through orthotopic injection of these cells into mammary fat pads of NOD/SCID mice.

Among the cultures containing oncospheres that did not self-renew, one (TP77) yielded a numbers of spheres sufficient to allow determining their tumor-initiating properties in vivo.

To determine their tumor-initiating properties, cell-forming spheres with self-renewing ability derived from three cultures (TP54, TP80, TP82) were grafted into the brains of nude or NSG mice, which were sacrificed 3.5 to 6 months post-graft.

Grafting of TP77-derived oncospheres in the brain of immunodeficient mice resulted only in a modest cell accumulation at the injection site (Figure 6A), showing that these cells devoid of self-renewal properties in vitro lacked also tumor-initiating properties in vivo.

Therefore, hollow spheroids may have acquired tumour-initiating properties.

Therefore, the majority of cells in DCIS.COM possessed tumor-initiating properties.