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The accumulation of Y-structures at OriP is most probably a consequence of replication initiating outside of OriP.
Starting with reads initiating outside the repeat region, the longest of the assembled reads were visually inspected for the presence of virB6 4 repeateat signature-sequences (Additional file 2: Figure S2) and their sequence manually corrected where necessary.
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Previous studies revealed that engagement of E-cadherin in homophylic calcium-dependent cell-cell interactions results in rapid PI3K-dependent activation of Akt, indicating that E-cadherin can initiate outside-in signal transducing pathways that regulate the activity of PI3K and Akt [51].
SLP-76 has been implicated in LFA-1-mediated outside-in signalling; however, T-cells were stimulated with the CXCR4 ligand stromal cell-derived factor-1α to initiate outside-in integrin signals [ 42].
Platelet adhesion through integrin α2β1 initiates outside-in signalling and activation of tyrosine kinases and small GTPases, including Rac1, which is involved in cross-talk between integrins in collagen-adherent platelets [ 89].
The majority of computers on the Stanford network have firewalls that are set by default to refuse all connections initiated from outside of Stanford University's network.
For example, a device being used as part of a robotics project on campus may not want or need SSH connections being initiated from outside of MITnet.
DoS attacks aim to deplete resources, including computation capability, bandwidth, memory, energy, etc. DoS attacks can be initiated from outside attackers as eavesdroppers or inside attackers.
The question is whether FIFA can now commit itself to real change, whether it's initiated from outside or within.
Since all PP1c isoforms can interact with αIIbβ3 (unpublished observation), one possibility is that the PP1cγ isoform does not participate in the functional responses initiated by outside-in integrin αIIbβ3 signaling.
By contrast, management actions leading to what we commonly label "change" are usually initiated outside the small work group by staff people.
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