Sentence examples for initiating nucleotide from inspiring English sources

Currently, only one Food and Drug Administration-approved NRTI, entecavir, a guanosine analog NRTI, can inhibit HP priming initiation by competing for incorporation with the initiating nucleotide, deoxy-guanosine triphosphate.

Oligonucleotides complementary to 5′ and 3′ ends of the fragment encoding Kanr were used for initiating nucleotide sequencing from the plus and minus strands of pSP70, and thereafter primer walking was used to determine nucleotide sequence of pSP70.

For TSSs identified by HTPS with promoter prediction, thymine was the most common initiating nucleotide (35%) while adenine was used in 31% of the cases.

This discrepancy may be due to the use of magnesium instead of manganese as the divalent metal and low concentrations of initiating nucleotide [14],[14].

The most frequent initiating nucleotide for mTSS transcripts was A (47.9%), followed by G (23.6%), T (14.8%), and C (13.7%).

RNA polymerases prefer to initiate at YR (−1, +1) sites, where the initiating nucleotide of an RNA is a purine, with a pyrimidine just upstream.

The determination of a crystal structure of a substrate complex for de novo initiation provided a firm foundation for structural modelling of relationships between GE and initiating nucleotides in a transcription initiation complex.

Using a combination of genetic, biochemical, and structural approaches, we show that the cyclic-peptide antibiotic GE23077 (GE) binds directly to the bacterial RNA polymerase (RNAP) active-center 'i' and 'i+1' nucleotide binding sites, preventing the binding of initiating nucleotides, and thereby preventing transcription initiation.

In conclusion, purines were more frequently utilized as initiating nucleotides.

We conclude that GE interferes with binding of initiating nucleotides to the RNAP i and i+1 sites.

GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.