Based on the apparent importance of the LPA-LPA1 pathway for the development of lung fibrosis, a Phase II clinical trial of an oral LPA1 antagonist for the treatment of IPF has recently been initiated (ClinicalTrials.gov identifier: NCT01766817).
However, no data on PDCD1 blockade in CLL are available yet, as a phase II study of anti-PDCD1 treatment in relapsed or refractory CLL has just been initiated (ClinicalTrials.gov identifier: NCT02332980).
In May 2008, the first Phase I clinical trial for the treatment of solid tumors involving systemic delivery of siRNA via targeted nanoparticles was initiated (ClinicalTrials.gov identifier: NCT00689065) [ 262].
HGT-GCB-058 was an investigational new drug treatment protocol (ClinicalTrials.gov identifier NCT00954460) initiated at the request of the FDA in 2009.
The query of PCAS for pre-computed proteome annotation data is initiated with a protein identifier, for example, the SPTR or IPI protein ID or AC.
Gene queries can be initiated using locus identifiers, database accessions, gene names and protein functions.
18 Therefore, we initiated the ROBOT trial (ClinicalTrial.gov identifier: NCT01544790) in January 2012 to compare RAMIE with open transthoracic esophagectomy.
The global aHUS Registry (US National Institutes of Health www.ClinicalTrials.gov Identifier NCT01522183) was initiated in April 2012 with the support of Alexion Pharmaceuticals, Inc.
Based on the promising results from the phase 2 dose-ranging study, the first phase 3 trial of a JAK inhibitor (ruxolitinib) in the treatment of PV, Randomized Study of Efficacy and Safety in Polycythemia Vera with JAK Inhibitor INCB018424 Versus Best Available Care (RESPONSE; ClinicalTrials.gov identifier, NCT01243944), was initiated; results were recently reported [ 61].
The Vanderbilt University Investigational Review Board approved the present study, and written informed consent was obtained from each subject before initiating the study (http://www.ClinicalTrials.gov identifier NCT00580619).
When a peer deals with the MapReduce operations, the group handler running on a separate process starts a thread to initiate a group with a unique identifier.
