Activated PKR phosphorylates eukaryotic translation initiating factor 2α (eIF2α) and thus inhibits translation [70], [77].
If vasoregression indeed cannot be identified in ZF rats, this would finally support the role of hyperglycemia as initiating factor.
Whatever the initiating factor of osteoarthritis (OA), the process ultimately unmasks the immunogenic determinants of chondrocytes, proteoglycans and collagens, which then triggers autoimmune reactions.
MCP-1 is an initiating factor and biomarker of atherosclerotic diseases.
Among direct transcriptional targets of the stomatal initiating factor, SPEECHLESS, a pair of genes, SOL1 and SOL2, are required for effective transitions in the lineage.
In both pathological states, peroxynitrite is the common initiating factor of oxidative stress and excitotoxicity and is thus a potential interesting therapeutic target.
Due to the structure difference, there will be cross flow between fuel assemblies, which may be the initiating factor for fuel leaks.
My contributions:One line of research I followed was to investigate the role of founder events, the founding of new populations by one or a few individuals, producing an extreme population bottleneck, as an initiating factor in speciation.
While clinical studies show that a loss of the microvascular circulation precedes and may act as an initiating factor for the development of chronic rejection, preclinical studies demonstrate that improved microvascular perfusion during acute rejection delays and attenuates tissue fibrosis.
This is an entirely natural phenomenon and it is worth noting that such amplification of temperature fluctuations will occur in response to any initiating factor regardless of its source and including human-produced greenhouse gases.
