Exact(2)
The observation that ETN abolishes myogenic responsiveness and the associated molecular/cellular events (Fig. 4i l) positions TNF as a mandatory and constitutive initiating element of myogenic signalling.
The response seems to be an instinctive mechanism for self-defense and, in humans, is probably the initiating element of more general emotional reactions, both motor expressions and conscious experiences.
Similar(58)
26 Well intentioned efforts to automate use of evidence through computerised decision support systems, structured templates, and point of care prompts can crowd out the local, individualised, and patient initiated elements of the clinical consultation.
However, the cis-acting elements involved in spreading heterochromatin along the ∼155-Mb chromosome from the initiating elements in the X inactivation center remain unknown.
In the absence of such translation initiating elements, transcription from the iTSS presumably results in a non-coding RNA as exemplified by the HgcC transcripts.
This indicates that PKC was required to initiate the element that was responsible for the potentiation, but not for its operation.
The White House press secretary issued a statement condemning "the violence initiated by elements of the armed forces of Mali" and calling for "the immediate restoration of constitutional rule".
It is quite possible that the high copy number of Alu elements allows for pairing between regions of sequence identity of different Alu elements initiating the start of gene conversion before cellular control systems can terminate the process resulting in the production of small gene conversion tracts.
I would also argue that the same element of humor that helps initiate laughter, the element of surprise, can also be an ironic catalyst of change.
Most importantly, the NF-κB pathway is directly involved in promoting Foxp3 expression, as c-Rel can bind to the CNS1 element (conserved noncoding sequence) within the promoter region, as well as to the CNS3 enhancer element, thereby initiating chromatin remodeling and leading to an open chromatin conformation at the foxp3 locus [57].
HSF1 trimerises and relocates to the nucleus where it binds to the heat shock element (HSE), initiating transcription of HSP72.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com