Sentence examples for initiating driver from inspiring English sources

Starting from initiating driver mutations, this model depicts the stepwise acquisition of different driver mutations (early, intermediate, late and speedy drivers) during cancer evolution.

This is of course far from the evolutionary trajectory of spontaneous human tumours, in which the dominant oncogene does not necessarily correspond to the initiating driver alteration.

It is difficult to distinguish whether the variants we observe occur before or after the initiating driver mutations that herald tumorigenesis, but our analysis of paired samples does suggest that they can occur both early and late.

Therefore current evidence would seem to suggest that if a common initiating driver event exists it is not genetic, implicating other mechanisms in disease aetiology.

Oncogenic mutation of the Hras gene is one of the initiating drivers in the development of benign papillomas and malignant squamous cell carcinomas in murine skin chemical carcinogenesis.

Malignant changes in the cellular genome can either be tumor-initiating driver events or subsequent adaptations required for tumor cell progression.

The main driver initiating the RecA monomer dissociation is hydrolysis of the ATP, and when ATPγS is used as the cofactor, the filaments are essentially stable.

The first interval, I 1, starts at time t 0 when the overtaking car initiatesbraking, and ends at time t 1 when the truck driver initiates evasive braking.

If so, when the truck driver initiates the evasive steering, there are no crucial differences in road position, speed, or headway to the lead vehicle, regardless of the test setting (unexpected or repeated).

The overtaking vehicle starts to brake at time t 0,and the truck driver initiates braking at time t 1 Open image in new window Fig. 3 A typical steering signal extracted from actual driving data.

Since in the present study neonatal growth trajectories in pups that were exposed to maternal undernutrition began to deviate from those of control pups at a time that coincides with a neonatal surge in circulating leptin concentrations, which itself is nutritionally influenced [49], [50], leptin may be a central driver in initiating maturational changes.