Sentence examples for initiating capability from inspiring English sources

The cancer stem cell theory suggests that a fraction of the cancer cell population is enriched for tumor initiating capability, thus requiring preferential targeting to achieve therapeutic benefits.

Moreover, the tumor initiating capability was not decreased as the spheres were passaged.

Finally, the link between MAT inducing treatments and tumour initiating capability has been validated in vivo.

Together, these data demonstrate that Six1 overexpression in luminal MCF7 breast cancer cells significantly increases the tumor initiating capability of these cells.

We tested the third, sixth and ninth generations of the PLC/PRF/5 sphere-forming cells for their tumor initiating capability.

To inspect whether the tumor initiating capability could be decreased as the spheres were passaged, we also compared the tumorigenicity of different generations of spheres.

Stem-like cells with tumour initiating capabilities have been found to be enriched in the CD44+/CD24-/low CD44+/CD24-/lowof basal breast carcinoma cells [ 6].

In addition, cells were analyzed by FACS for cell surface proteins which differentiate luminal versus basal/myoepithelial cells (EPCAM/CD49f)[ 25] and cancer cells with tumor initiating capabilities (CD44/CD24) [ 16].

We therefore initially isolated NCAM+PSA-NCAM+ or NCAM+CD44+ cell fractions from p-WT Xn by sorting and analysed their tumour initiating capabilities in mice as well as additional stemness characteristics.

Recent evidence suggests that some CTCs, referred to as circulating cancer stem cells, exhibit a stem-cell-like phenotype and may possess metastasis-initiating capabilities associated with resistance to therapy [63, 64].

We show that RARRES3 downregulation engages metastasis-initiating capabilities by facilitating adhesion of the tumor cells to the lung parenchyma.