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It is shown that catalytic residues act as initiating agents for the damage.
Infectious agents have long been suspected as initiating agents (etiology) of rheumatic diseases.
Alveolar hyperplasias are frequently observed in models where mouse mammary tumor virus, hormones or chemical carcinogens are the initiating agents.
The differentiation of breast cells that occurs during the third trimester of pregnancy makes them less sensitive, or insensitive, to initiating agents.
These observations together with the sharply decreasing number of co-regulated genes as a function of the number of stress initiating agents studied (Table 3) does not support the existence of a S. cerevisiae-type ESR in A. nidulans.
However, short-term tests are only theoretically correlated to carcinogenesis because their end points can measure only the genotoxic potential of chemicals, i.e., their activities as initiating agents in multistep carcinogenesis.
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Regardless of the nature of initiating agent, fibrogenesis phase sets in, which consists of inflammatory and proliferative responses regulated by chemokines, cytokines and growth factors.
The consensus is simply achieved: the not yet initiated agent follows the practice observed because communication would break down otherwise (no private language!).
We initiated agent number by directly counting the crowd during peak hours and use it as the base to construct the ABS.
Because options for adjusting for RA disease severity are limited in administrative claims, we selected a population of patients who had previously discontinued a different biologic agent prior to initiating the agents evaluated in this study.
Indirect evidence suggests that the initiating agent(s) in idiopathic achalasia may be viral.
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