Sentence examples for initiated through binding from inspiring English sources

Further studies discovered that the transcriptional activation of many regulatory genes is initiated through binding of a specific protein that is induced under hypoxia conditions to the HRE.

Both LMF and ZAG induce lipolysis directly in isolated adipocytes by a cyclic AMP-mediated process (Hirai et al, 1998) and this is initiated through binding to a β3-adrenoreceptor (AR) (Russell et al, 2002).

Activation of Hh signalling is initiated through binding of any of the above three ligands to a 12-transmembrane protein receptor, PTCH, which acts as a negative regulator of a 7-transmembrane protein, SMO.

Biological activity is initiated through adiponectin binding to the cell membrane receptors AdipoR1, AdipoR2 and T-cadherin.

Following its biosynthesis, gibberellin signaling in Arabidopsis is initiated through its binding to the GA INSENSITIVE DWARF1 (GID1) receptor.

In human cells, MMR is initiated through the binding of a heterodimer of hMSH2 with either hMSH6 (hMutS α) or hMSH3 (hMutS β) to the site of the mismatch or base insertion/deletion [ 13].

Activation of WNT signaling cascade is initiated through the binding of WNT with its receptor/co-receptor. WNT/β-catenin is the first indentified WNT pathway that is aberrantly activated in human colorectal cancer [ 15, 16].

In the endogenous signal pathway, a stress signal is initiated through the binding of activated Bax to the outer membrane of mitochondria to induce the release of apoptogenic factors such as cytochrome C into the cytoplasm.

The transcriptional activation of HIF-1 α target genes is initiated through the cooperative binding of C-TAD in the HIF-1 α and the co-activator CBP/p300.

Import may be initiated through a PTS1-binding induced conformational shift in the TPR domain [45] which facilitates opening of the PEX5 PEX14 transient pore [15].

Upon tyrosine phosphorylation, the IRS proteins initiate, through different binding mechanisms [20], various downstream signal transduction cascades, including c-Jun N-terminal kinase (JNK) [21], [22] and phosphoinositide 3-kinase (PI3K) [23], which in turn catalyze the formation of the lipid second messenger phosphatidylinositol-3,4,5-triphosphoate (PIP3).