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The model includes endogenous and radiation induced damage causing progression of cells from normal, to damaged, to initiated, to initiated damage, to malignant status.
However, contrary to earlier observations, later studies revealed that during the early phase of EAU (postimmunization day 5) retinal ONOO− initiated damage occurred before there was any histologic or immunohistochemical evidence of macrophage infiltration or migration of retinal microglia [6, 15].
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Since knots often initiate damage in structural timber parts, a failure criterion is applied in the area of the knots.
Both the case where abnormal loads are specified and the case where initiating damage levels are specified are considered.
Nicks are the most common form of DNA damage, but they have only recently been shown to initiate damage that requires repair.
Quasi-static impact tests were conducted on dry C/VE510A and C/VE8084 to estimate the threshold impact force required to initiate damage in the composites.
She hypothesized that deformation initiates damage, but that ischaemia causes the damage to grow faster than would otherwise be the case.
The cytosol of a cell maintains cellular homeostasis including redox potential, ionic levels, etc. Disruptions of such homeostasis (biomarkers of aging) will initiate damage to cells.
These findings raised the question whether pathogenic serum antibodies against AQP4 could also enter in sufficient concentrations to initiate damage to astrocytes.
Downregulation of innate immune cells to minimize their activation of adaptive immunity, and their ability to invade and initiate damage target tissues should result in not only less active acute disease but also less future damage.
A light-absorbing photosensitiser (Ps) is endocytosed and then stimulated by light, inducing transfer of energy to a cytoplasmic acceptor molecule and the generation of reactive oxygen species that initiate damage to cellular membrane components and cytolysis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com