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By analogy to our findings for yeast, slowing the exchange of Rop2 may impair competition in that system, allowing more than one site to initiate tip growth.
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The lack of functional rescue after transgenic endothelial dll4 expression suggests however a role for Wnt/β-catenin during CNS angiogenesis that goes beyond initiating tip and stalk cell fate decisions through Notch ligand transcriptional control.
Fatigue cracks always initiate at the tip of hooking defect in the RS of SPW and AS of DPW joints respectively.
Cracks initiate at the tip of the notch, where stress and strain are concentrated, and then propagate intergranularly when the degree of triaxiality exceeds a critical level.
Small elevation changes were also noted, such as doorway thresholds and sidewalk cracks or heaves, which can catch the front casters and initiate a forward tip.
Both types of cracks initiate from the tips of the fractures and propagate in a stable manner.
Due to the high permeability of pre existing rock joints, fractures prefer to initiate at joint tips after the joint is intersected by a fluid driven fracture.
In the second orientation similar short ( left[10overline{1}right] ) direction cracks initiate from the tips of the indentation {001} diagonal and cracking also occurs in a plane parallel to the surface due to partial cleavage on the (010) planes.
After primary flap closure, closed coil springs were activated to apply 200 g orthodontic force in the buccolingual direction and initiate immediate buccal tipping movement of the second and third premolars, in the control and test sides.
By analyzing the stress surrounding the oval flaw periphery, we explain that the wing tensile crack initiation area transfers from the middle of the oval flaw periphery to the tip of the oval with increasing oval flaw angle, shear crack is easily initiated at the tip of the oval flaw, and the stress of the first wing crack increases with increasing oval flaw angle.
Stress concentration at defect tips can initiate crack propagation and induce fractures in these materials [8].
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