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The guide RNA in the CRISPR-Cas immune/editing system is poised to initiate recognition of target DNA.
In the TCR pathway, the XPC HR23B complex is not required and RNA polymerase is believed to initiate recognition, leaving the role of XPA unclear [ 14].
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Lipopolysaccharide-binding protein (LBP), an acute-phase protein synthesized in liver, initiates recognition and monomerization of LPS and amplifies host responses to LPS (10).
The communities along the Ribeira de Iguape River initiated recognition processes in the beginning of the 1990s as a strategy against the construction of a series of planned hydropower dams.
Colonisation may have initiated recognition of the biological changes associated with menopause, yet the preferred use of the term 'change of life' indicates more of a natural transition in which biological assistance or intervention may not be desired.
At normal oxygen tensions, the α-subunit of the protein (Hif-1α) undergoes prolyl hydroxylation, which initiates recognition by the von Hippel Lindau (Vhl) tumor suppressor protein, a component of the E3 ubiquitin ligase that targets Hif-1α for proteasomal degradation.
This may be sufficient to initiate a recognition response in vivo.
Macrophages expose phosphatidylserine receptors, which efficiently initiate the recognition and subsequent removal of apoptotic cells [ 33, 34].
Such differences in outcome may be attributed to the ability of APCs to recognize and internalize smaller particles by phagocytosis, while larger particles may only initiate APC recognition and adherence.
Most bulk protein synthesis is initiated via recognition of the mRNA 5′ cap and subsequent recognition of the initiator AUG codon by a directional scanning mechanism.
13 Although medication for pain may be initiated, delayed recognition of depression and initiation of antidepressant treatment may negatively affect the course and severity of illness and result in poorer treatment outcomes.
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