Sentence examples for initiate mutation from inspiring English sources

We have pooled the three ancestral mutations in our analyses, because if a woman has a sufficiently high probability of being a carrier to initiate mutation testing, the extra work and expense to test for all three mutations is relatively small given that she will have already gone through counselling and provided a blood sample from which DNA had been extracted.

Various polycyclic aromatic hydrocarbon compounds can be used to initiate mutations for the induction of skin cancer (e.g., 9,10-dimethyl-1,2-benz-anthracene/DMBA, benzopyrene/BaP, methylcholantrene/MCA).

We have initiated mutation screening of suspected HBOC families to improve health care for affected individuals and their asymptomatic relatives in the Slovak Republic.

As the mutational spectrum of the BRCA1 and BRCA2 genes in the Belgian patient population is largely unknown, we initiated mutation analysis for the complete coding sequence of both genes in Belgian families with multiple breast and/or ovarian cancer patients and in "sporadic" patients with early onset disease.

Our understanding of initiating mutations in de novo AML is derived from studies of mutational allelic burden, stability of mutations through the disease course, patterns of co-occurrence between mutations, specificity for a particular AML phenotype and mechanistic studies of the properties of specific mutations.

As for PML-RARA, indirect evidence from mouse models suggests that mutated NPM1 and fusion proteins of CBFB, RUNX1 and MLL are initiating mutations for AMLs (reviewed in McCormack et al).. AML mutations were separately analyzed in each of the AML subgroups.

However, lack of knowledge of initiating mutations and the target 'cell of origin' has slowed progress towards this goal.

These findings suggest that regulation of initiating mutations may not be sufficient to control tumorigenesis.

It is thus critical to identify these other signalling pathways that cooperate with these presumably initiating mutations to drive cancer.

It should be noted that adjacent normal tissue may still contain initiating mutations that are important for subsequent cancer progression.

Therefore, initiating mutations drive senescence in a tissue-specific manner and shape the evolutionary landscape for the subsequent mutations that allow tumour progression.