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It can recruit monocytes, memory T cells and dendritic cells to the site of injury, infection and inflammation, then initiate factor of inflammatory cytokine network.
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Activated PKR phosphorylates eukaryotic translation initiating factor 2α (eIF2α) and thus inhibits translation [70], [77].
If vasoregression indeed cannot be identified in ZF rats, this would finally support the role of hyperglycemia as initiating factor.
Whatever the initiating factor of osteoarthritis (OA), the process ultimately unmasks the immunogenic determinants of chondrocytes, proteoglycans and collagens, which then triggers autoimmune reactions.
The fact that children can develop metabolic syndrome suggests that while obesity and aging contribute to the syndrome, it is unlikely that they are initiating factors.
MCP-1 is an initiating factor and biomarker of atherosclerotic diseases.
In both pathological states, peroxynitrite is the common initiating factor of oxidative stress and excitotoxicity and is thus a potential interesting therapeutic target.
Due to the structure difference, there will be cross flow between fuel assemblies, which may be the initiating factor for fuel leaks.
These data suggest not only the probable initiating factor and mechanism for cell death, but also a potential protective strategy.
Our data support that placentally-mediated reduction in glucose transport is an initiating factor for reduced fetal growth under conditions of chronic hypoxemia.
The molecular events that mediate neuronal PrPc to PrPsc conversion, not simply accumulated PrPsc, appears to be the initiating factor mitigating the neurodegenerative disease process [5].
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