Sentence examples for initiate assembly from inspiring English sources

The "handle" in soluble fibronectin that cells use to initiate assembly, however, is located in the N-terminal F1 and F2 modules, not the RGD-containing F3 module recognized by α5β1 and several other integrins [11].

To initiate assembly, nPA K563C*AF555 and nPA K563C*AF647 were each diluted to 50 nM in 10 mM sodium cacodylate, 100 mM potassium chloride, 1 mM magnesium chloride, pH 7.4 either in the presence or absence of 100 nM LFN, 100 nM msANTXR2, or 100 nM dsANTXR2.

This observation suggests that multiple weak interactions between protofibrils are required to initiate assembly.

These POTRA domains are not essential for Sam50 to function, with the metaxin Sam35 serving as the 'receptor' for β-barrel substrates to bind the SAM complex and initiate assembly (Chan & Lithgow, 2008; Kutik et al., 2008).

Together, these data demonstrate that the substitutions at two of Sir2's targets: H3K4 and H4K16, with residues that mimic the lack of charge of an acetylated residue, do not impede the ability of Clr4 to initiate assembly of centromeric heterochromatin.

2) As the authors note, CD4 downregulation is the "classic" function of Nef, and this study explains the molecular basis for half of that interaction, explaining how Nef recruits the AP-2 complex to initiate assembly of a clathrin coated pit.

The Rpn11 subunit initiates assembly of a five-subunit lid module competent to integrate into pre-assembled base-20S core particle (CP), with subsequent recruitment of remaining lid subunits.

Two recent reports further emphasize the importance of properdin in the AP: Spitzer et al. [52] and Kimura et al. [53] showed that properdin can also bind directly to microbes, initiating assembly of C3BbP convertase and complement activation.

Binding of TRAIL to DR4 and DR5 initiates assembly of the death-inducing signaling complex (DISC), which directly triggers caspase activation and, in some cells, activates the mitochondrial apoptotic pathway.

It is tempting to speculate that integrin recognition of collagen, a pro-morphogenic substrate for ECs [ 63], initiates assembly of a molecular complex composed of α2β1, MT1-MMP, and caveolin Tyr at the cell surface that is stabilized by vimentin to facilitate endothelial morphogenesis and sprouting events.

Moreover, ER-associated lipid droplets are the viral assembly sites where the nucleocapsid protein core and the replication complex interact to initiate capsid assembly [ 101].