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The UPR initially promotes cell survival; however, when overwhelmed, it initiates pro-apoptotic pathways involving signalling to B-cell lymphoma protein 2 (Bcl-2) family proteins located at mitochondria (Szegezdi et al, 2009).
Otx2 is involved in a regulatory partnership with Oct4 wherein Oct4 initially promotes Otx2 expression.
Likewise, we found that IGF-1 treatment initially promotes proliferation and later induces senescence in a SIRT1/p53-dependent manner.
Also, very few splenic nerve fibers contain vasointestinal peptide (VIP) and CRH., As mentioned above, NA initially promotes the TH1 response.
ATF4 target genes include amino acid transporters, anti-oxidant response genes, angiogenic factors, and protein chaperones, and thus, ATF4 initially promotes cell survival against these insults (Jain, 2005; Roybal et al., 2005; Han et al., 2013).
It may be supposed that temporal expression of HO-1 initially promotes myoblasts proliferation, as suggested by increase in Pax7 expression and decrease in MyoD and myogenin expression at early phase of regeneration in muscle overexpressing HO-1.
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Spheroidal morphology is initially promoted by chemical precipitation from evaporating solutions around grains.
Even console manufacturers like Microsoft and Sony, which initially promoted the online potential of their machines, have been reluctant to proceed.
And finally, Khubilai's economic policies in China, at least initially, promoted the interests of China and were quite successful.
Firstly, discovery of AQP1 in the lumen-facing membrane of choroid plexus initially promoted its implication in CSF production13,15,27.
Assuming that proteolysis is facilitated primarily in the cytoplasm, transcriptional activation may be initially promoted by a small amount of E3 proteins that preferentially localize in the nucleus.
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