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These examples illustrate how GRN inference can productively be combined with downstream analysis: a GRN is initially inferred from experimental data, features of interest are identified based on network topology and interesting features are then ranked by applying additional criteria derived from experimental evidence, functional annotation or literature.
For days, if you were a Twitter user, Ferguson dominated your tweetstream, to the point where one of my acquaintances, returning from a holiday off the grid, initially inferred from the trending hashtag "#ferguson" that Sir Alex had died.
Social organization initially inferred for each colony in the field was definitively determined in the following way.
The occurrence of long-term potentiation of responses after high-frequency rTMS was initially inferred on the basis of behavioral changes [20], [21] and especially of increased motor evoked potential amplitude to test TMS stimuli [12] [14], [22].
The evolutionary relationships of dinoflagellates were initially inferred from a comparison of morphological characters [15], and these data are very important for evaluating weakly resolved branching patterns inferred from molecular markers [13], [16].
Thus, MLST data fully confirm the clonal nature of clones I to III, which was initially inferred from several characteristics including PFGE, protein profile, AFLP or ribotyping [7], [8].
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This unexpected result led us to initially infer that removal of hepatic GSK-3α is insufficient to reproduce the whole body improvement of glucose metabolism that is observed with the global GSK-3α KO mouse.
Although, based on the longer half-life of mutant p53, one might initially infer that most of the accumulation is due to overexpression of mutations in p53, overexpression of wild-type p53 would also be detected by this antibody (Gannon et al, 1990).
Social organization of each colony initially was inferred in the field on the basis of nest distribution patterns, worker size distributions, and observation of multiple dealate queens (see Table 1 for terminology) [4], [39], [40].
The biologic function of the Gsdm/GSDM family genes initially was inferred from phenotypes of spontaneous and chemically-induced mouse mutants.
Initially, LOH regions were inferred in a small cohort of B-CLL patients using the Cohort Heterozygosity Comparison method.
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